Efficient Fuel Guide

Could Antimatter Be The Only Possible And The Most Efficient Fuel Source To Get To The Nearest Star Under The Human Life Span, Considering That It Would Take 40 Years To Get To Alpha Centauri And That It Would Only Take About Four Grams Of The Antimatter?

And The Fuel Source Would Be As The Result Of Colliding Antimatter And Matter, Thus Resulting In The Creating Of An Enormous Amount Of Energy.
Don't Forget That That Antimatter Engine Could Bring The Spaceship You're In Up To 10% The Speed Of Light.